Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed. Medically reviewed by Drugs.com. maraviroc, isosorbide mononitrate. Imdur may interact with sildenafil, other vasodilators, alcohol, calcium channel blockers, and organic nitrates. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. ), Increase dose at an interval of 3 - 5 days, Food increases absorption. David McAuley, Pharm.D. Monitor Closely (1)isosorbide mononitrate, captopril. [9]. Use Caution/Monitor. This effect was not observed with istradefylline 20 mg/day. Use Caution/Monitor. Isosorbide dinitrate: About 1 hour. After . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Adjust dose of drugs that are CYP3A4 substrates as necessary. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Several well-controlled clinical trials have used exercise testing to assess the anti-anginal efficacy of continuously-delivered nitrates. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs. Modify Therapy/Monitor Closely. The target does is 20 mg twice daily. The bioavailability of ISDN varies widely, and it undergoes significant . Either increases effects of the other by pharmacodynamic synergism. No specific dosage recommendations for hepatic impairment. Importance of consulting clinician if headache continues with repeated dosing. Isosorbide dinitrate or mononitrate is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long-term prophylactic management of angina pectoris. %&SC*U]0l TCLg&=|G==!bT=4Er R|qB^RzA-C%#^krR(Luhiy7c+>Vour]ZOf?HV Avoid or Use Alternate Drug. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Modify Therapy/Monitor Closely. Risk of increased SBP, angina pectoris. In the large majority of these trials, active agents were indistinguishable from placebo after 24 hours (or less) of continuous therapy. Importance of informing patients of other important precautionary information. tucatinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).Isosorbide mononitrate is very similar to isosorbide dinitrate. Mechanism: additive vasodilation. Isosorbide dinitrate (Isordil) is good for a specific type of chest pain (called angina), but it can cause headaches after you take it. Use Caution/Monitor. Mechanism: additive vasodilation. This effect was not observed with istradefylline 20 mg/day. If you have specific questions regarding a drugs safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information. Make sure laboratory personnel and all your doctors know you use this drug. Medscape Education. Peripheral venous resistance is decreased via a selective action on venous capacitance vessels and results in venous pooling of blood and decreased venous return to the heart. primidone will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Other medications may be prescribed by your doctor for these conditions. Use Caution/Monitor. It has not been studied in liver disease. The recipient will receive more details and instructions to access this offer. phenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088. It will remain primed for 6 weeks. Allow 48h after last tadalafil dose before nitrate administration. Monitor Closely (1)nitroglycerin rectal, isosorbide mononitrate. Use Caution/Monitor. Imdur ( isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease. Do not rinse mouth for 5 - 10 minutes following spray, Administer one or two packets (400 mcg of NTG) under the tongue at the onset of an attack, One additional packet may be administered every five minutes as needed, No more than three packets are recommended within a 15-minute period, 1 packet 5 - 10 minutes prior to engaging in activity, Administer at rest, ideally in the sitting position. Minor/Significance Unknown. Caution if used in nursing women. Use caution. Rutherford JD. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Potentially fatal hypotension. Contraindicated (1)isosorbide mononitrate, riociguat. Isosorbide dinitrate (isordil ) Isosorbide mononitrate (ismo , monoket ) Dosing: Angina: Regular release tablet: 5-10 mg twice daily with the two doses given 7 hours apart (8am and 3pm) to decrease tolerance development - then titrate to 10 mg twice daily in first 2-3 days. To apply the ointment using one of the applicators, place the applicator on a flat surface, printed side down. All Rights Reserved. Tight, light-resistant containers at room temperature (25C); do not expose to extremes in temperature. Potentially fatal hypotension. Always ask your health care professional for complete information about this product and your specific health needs. Dosage form: tablet, extended release Other (see comment). Consult your doctor for more details. tetracaine, isosorbide mononitrate. By clicking send, you acknowledge that you have permission to email the recipient with this information. Mechanism: additive vasodilation. Conventional measures in the management of angina pectoris are aimed at reducing the frequency, duration, and severity of attacks, and include coronary risk reduction (e.g., discontinuance of smoking, weight control, antilipemic strategies), rest, avoidance of precipitating circumstances (e.g., eating heavy meals, getting emotionally upset, performing strenuous exercise, exposure to cold air) and, if possible, treatment of the underlying cause. Contraindicated (1)isosorbide mononitrate, vardenafil. Isosorbide dinitrate is contraindicated in patients with shock or marked low blood pressure. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Monitor Closely (1)primidone will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This effect was not observed with istradefylline 20 mg/day. Isosorbide dinitrate and isosorbide mononitrate are mainly excreted in the urine. ChildrenUse and dose must be determined by your doctor. Avoid or Use Alternate Drug. Risk of elevated blood concentrations of isosorbide dinitrate in patients with cirrhosis. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Modify Therapy/Monitor Closely. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Parker JD. Your doctor may increase your dose as needed. This strategy is inappropriate for organic nitrates. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Dose adjustments do not appear to be necessary in kidney disease. Modify Therapy/Monitor Closely. Either increases effects of the other by additive vasodilation. Use Caution/Monitor. Do not store in the bathroom. Copyright 2023, Selected Revisions February 7, 2017. Fexinidazole inhibits CYP3A4. Comes in 4.1g (90 sprays) and 8.5g (230 sprays) bottle. tecovirimat will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prime bottle with 5 sprays. It does not work fast enough to relieve the pain of an angina attack that has already started. Monitor Closely (1)isosorbide mononitrate, bupivacaine implant. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Parker JO. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Thus, one appropriate dosing schedule for NITRO-BID would begin with two daily 1/2- inch (7.5 mg) doses, one applied on rising in the morning and one applied six hours later. Avoid or Use Alternate Drug. Keep all medical and lab appointments. Risk of increased SBP, angina pectoris. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Headache is often a sign that this medication is working. Use Caution/Monitor. Contraindicated. Monitor blood pressure. -Adrenergic blocking agents (-blockers) generally are considered among the initial antianginal drugs of choice in the long-term prophylactic management of chronic stable angina with or without prior MI to reduce symptoms and to prevent MI and/or death. Advise patients to take nitrates as directed, particularly since tolerance can occur. Avoid or Use Alternate Drug. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Use Caution/Monitor. isosorbide mononitrate, vardenafil. Dilatation of the coronary arteries also occurs. The level of glutathione S-transferases (GSH-ST) determined by following the reactions with of 1-chloro-2,4-dinitrobenzene (CDNB), o-dinitrobenzene (o-DNB) or . Either increases toxicity of the other by Other (see comment). No specific dosage recommendations for renal impairment. Distribution into human body tissues and fluids has not been fully characterized. May induce methemoglobinemia. A local search option of this data can be found here. Tight, light-resistant containers at 25C; may be exposed to 1530C. Indications Angina (a specific type of chest pain) caused by heart disease Chest pain caused by angina Pros and Cons Pros Good at preventing chest pain caused by heart disease Use Caution/Monitor. Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). elagolix decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by Mechanism: additive vasodilation. Isordil (isosorbide dinitrate) is a nitrate indicated for the prevention of angina due to coronary artery disease and congestive heart failure. Risk of increased SBP, angina pectoris. Supplied: Capsule, sustained release (Dilatrate-SR): 40 mg Tablet: 5 mg, 10 mg, 20 mg, 30 mg, 40mg Tablet, extended release (Isochron): 40 mg Sublingual tablet: 2.5 mg, 5 mg. Use Caution/Monitor. Mechanism: additive vasodilation. Controlled trials with other formulations of nitroglycerin have demonstrated that if plasma levels are maintained continuously, all anti-anginal efficacy is lost within 24 hours. Why Use Isosorbide Dinitrate vs Isosorbide Mononitrate? It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Adjust dose according to prescribing information if needed. Copyright 2021 GlobalRPH - Web Development by. This tolerance cannot be overcome by increasing the dose of nitroglycerin. Elagolix is a weak-to-moderate CYP3A4 inducer. IMDUR, generics Dosage Forms 100 mg/250 mL premixed bottle - UHN Note: 0.84 mL alcohol per 100 mL solution 100 mcg/mL 200 mcg/mL 400 mcg/mL 10 mg/10 mL . Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergoloid mesylates by decreasing metabolism. Monitor Closely (1)isosorbide mononitrate increases toxicity of dapsone topical by altering metabolism. National Institutes of Health, U.S. National Library of Medicine, DailyMed Database. fexinidazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. AdultsAt first, 30 or 60 milligrams (mg) once a day. Do not use extended-release isosorbide dinitrate preparations or any isosorbide mononitrate preparation to abort an acute anginal episode or for acute relief of angina or in the prophylactic management in situations likely to provoke angina attacks; onset is not sufficiently rapid. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Avoid or Use Alternate Drug. May titrate dosage to a maximum tolerated dosage not to exceed 2 tablets (a total of 40 mg of isosorbide dinitrate and 75 mg of hydralazine hydrochloride) 3 times daily. Pharmacokinetics: The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at extremely rapid rates, with a resulting serum half-life of about three minutes. (See Geriatric Patients under Dosage.). mitotane decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Although many clinicians do not gradually reduce the dosage when discontinuance of oral nitrates is planned, it appears prudent that dosage be gradually reduced (e.g., over a period of about 12 weeks) to avoid withdrawal manifestations. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease. 1996-2023 RxList, Inc. All rights reserved. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Current guidelines recommend a combination of drug therapies (e.g., ACE inhibitors, angiotensin II receptor antagonists, angiotensin receptor-neprilysin inhibitors [ARNIs], -blockers, aldosterone receptor antagonists) in adults with heart failure to reduce morbidity and mortality. Contraindicated. 1 - 2 sprays on or under the tongue at the onset of pain. The dose can be increased to 10 mg twice daily after 2 to 3 days. This information is not individual medical advice and does not substitute for the advice of your health care professional. '~|4+TYG_X7b0-umj-&0=5Gf37{h73?}vQ8V:/-%c:y S`(0hIk i[j_ {?Mkpr | C+{wC7Rl
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Q@?gB kCRt)tmlx &>AwVqF+|UGFhGEV=AVofypRu"8F=bj Dosage adjustment of either the nitrate/nitrite or the other agent with hypotensive activity may be necessary to avoid orthostatic hypotension during concomitant use, Disopyramide may reduce the efficacy of isosorbide dinitrate, Antimuscarinic actions of disopyramide may decrease salivary secretions and thereby inhibit the dissolution of the sublingual tablets, Dihydroergotamine may counteract the coronary vasodilatory effect of nitrates, Use concomitantly with caution; risk of angina precipitation, Patients receiving nitrates or nitrites concomitantly should be observed for possible additive hypotensive effects, Use concomitantly with caution; may need to adjust dosage to avoid orthostatic hypotension, Phosphodiesterase (PDE) inhibitors, selective, Sildenafil and other selective PDE inhibitors (e.g., tadalafil, vardenafil) profoundly potentiate the vasodilatory effects (e.g., a >25-mm Hg decrease in SBP) of organic nitrates and nitrites (e.g., nitroglycerin, isosorbide dinitrate), and potentially life-threatening hypotension and/or hemodynamic compromise can result, Because of the serious risk of concurrent use of organic nitrates or nitrites and selective PDE inhibitors, such combined use is contraindicated, If consideration is given to administering a nitrate or nitrite after a PDE inhibitor (e.g., >24 hours after sildenafil use), the response to the initial doses must be monitored carefully and proper facilities for fluid and vasopressor (e.g., -adrenergic agonists) support must be readily available to prevent acute ischemic episodes, Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction causing a false report of decreased serum cholesterol. Stiripentol is a CYP3A4 inhibitor and inducer. !W#Lgy Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Monitor Closely (1)dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Start with lower doses and titrate slowly. commonly, these are "preferred" (on formulary) brand drugs. To help you remember, take it at the same times each day. Avoid or Use Alternate Drug. Both drugs lower blood pressure. Either increases effects of the other by pharmacodynamic synergism. Tape applicator in place. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. An interdosing interval sufficient to avoid tolerance to Dilatrate-SR extended-release capsules is not known, but it must exceed 18 hours. Use Caution/Monitor. <>>>
Isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) is prescribed for the treatment of angina (heart pain), coronary artery disease, and congestive heart failure. Avoid or Use Alternate Drug. Conventional tablets (e.g., Monoket): Tight, light-resistant containers at 1530C. Each tablet, for oral administration, contains 120 mg of isosorbide mononitrate in an extended-release formulation. Do not double the dose to catch up. Importance of clinicians unfamiliar with their patients drug history, especially those involved in emergency care (e.g., for presumed myocardial infarction or ischemia), to take a careful history so that concomitant use with selective PDE inhibitors can be avoided. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Use Caution/Monitor. acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. x][7~_cNv2}LN
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J{{or`}|4^r Coverage of an area approximately the size of the dose-measuring applicator (3 1/2" by 2 1/4") should be sufficient to obtain the desired clinical effects. Monitor Closely (1)stiripentol, isosorbide mononitrate. endobj
and formulary information changes. For oral dosage form (tablets): Adults20 milligrams (mg) two times a day. dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Evaluate for loss of therapeutic effect if medication must be coadministered. Initially, isosorbide dinitrate 20 mg and hydralazine hydrochloride 37.5 mg (1 tablet of BiDil) 3 times daily. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia. dichlorphenamide and isosorbide mononitrate both decrease serum potassium. Warn all patients taking either selective PDE inhibitors or organic nitrates or nitrites of the potential consequences of taking the drugs within close proximity (e.g., within 24 hours of sildenafil; possibly more prolonged periods of risk with longer-acting PDE inhibitors) of taking a nitrate- or nitrite-containing preparation. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Benefits in acute MI and heart failure not established. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Contraindicated. Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. isosorbide mononitrate, arginine. imdur - UpToDate Adult Patient Graphics Showing results for Imdur (Isosorbide mononitrate) Search instead: Nitrates Nitrates in the management of chronic coronary syndrome sustained-release once-a-day preparation since it can be given once daily. Use Caution/Monitor. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Selective PDE inhibitors can potentiate the hypotensive effects of organic nitrates and nitrites, possibly resulting in potentially life-threatening hypotension and/or hemodynamic compromise. Titrate dosages to levels similar to those recommended for the fixed-combination preparation and administer both drugs at least 3 times daily. Avoid or Use Alternate Drug. Minor/Significance Unknown. Initially, isosorbide dinitrate conventional tablets (e.g., Isordil Titradose) 520 mg administered 23 times daily, followed by maintenance dosage of 1040 mg administered 23 times daily (some patients may require higher dosages). Manufacturers of selective PDE inhibitors (e.g., sildenafil, tadalafil, vardenafil) state that the drugs are contraindicated in patients receiving organic nitrates or nitrites in any form (e.g., orally, sublingually, transmucosally, parenterally), given regularly or intermittently, or nitric oxide donors since severe, potentially fatal hypotensive episodes can occur. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). anastrozole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sign Up Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Individual plans may vary Avoid or Use Alternate Drug. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Drugs 1995;49:196-9 3. VA class: CV250 Maximum 40 mg of isosorbide dinitrate and 75 mg of hydralazine hydrochloride (2 tablets of BiDil) 3 times daily. This site complies with the HONcode standard for trust- worthy health information: verify here. Comment: Acetylcysteine may enhance vasodilatory effects of nitrates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To avoid development of tolerance to nitroglycerin, drug-free intervals of 10 - 12 hours are known to be sufficient; shorter intervals have not been well studied. Postural hypotension may occur and may cause dizziness, weakness, and other signs of cerebral ischemia. Otherwise, call a poison control center right away. conivaptan will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)nafcillin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Monitor Closely (1)tecovirimat will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This information does not assure that this product is safe, effective, or appropriate for you. Adjust dose of drugs that are CYP3A4 substrates as necessary. Serious - Use Alternative (1)isosorbide mononitrate increases effects of methylergonovine by decreasing metabolism. The antihypertensive therapy immediately before starting ISMN ( Table 1) consisted of 2 to 4 of the following drugs, administered in conventional dosage: diuretics (hydrochlorothiazide 25 to 12.5 mg/d [8 cases], amiloride 5 mg/d [2 cases], indapamide 2.5 mg/d [3 cases], aldactone 50 mg/d [1 case]); -blockers (atenolol 50 to 100 mg/d [4 cases], Monitor Closely (1)rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)efavirenz will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 1 - 2 sprays onto or under the tongue at the onset of pain. Avoid or Use Alternate Drug. Brand names: Dilatrate, Imdur, Ismo, Isordil, Monoket Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. drip: Immediate, Duration: Sublingual tablet: 30-60 minutes; Translingual spray: 30-60 minutes; Buccal tablet: 2 hours; Sustained release: 4-8 hours; Topical: 2-12 hours; Transdermal: 18-24 hours; I.V. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Particularly small stature, maintenance: Increased to at least 10 mg twice daily by the second or third day. The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of a 60 mg tablet) or 60 mg (given as a single tablet) once daily. Each tube of ointment and each box of foilpacs is supplied with a pad of ruled, impermeable, paper applicators. Contraindicated. Subsequent studies discovered that a chemical reaction between . This dose should be increased to 10 mg by the second or third day of therapy. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Potentially fatal hypotension. Tell your doctor all medications and supplements you use. Avoid or Use Alternate Drug. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Monitor Closely (1)duvelisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)isosorbide mononitrate, arginine. Maximum 120 mg daily administered concomitantly with hydralazine hydrochloride (maximum 300 mg daily). Modify Therapy/Monitor Closely. Use Caution/Monitor. Isosorbide dinitrate or mononitrate can be used alone or in combination as either second-line or third-line therapy in patients previously treated with a -blocker. 3 0 obj
Information last revised December 2022. Must be coadministered adjust dose of drugs that are CYP3A4 substrates as necessary visiting the drug. Local search option of this data can be used alone or in combination as second-line. Observed with istradefylline 20 mg/day primidone will decrease the level or effect of isosorbide mononitrate, arginine nitrites! Receive more details and instructions to access this offer tolerance to Dilatrate-SR extended-release is... To coronary artery disease and congestive heart failure the large majority of these trials, active agents were indistinguishable placebo. A strong CYP3A inhibitor and may lead to increased plasma levels of predominantly... One or more of these preparations cause methemoglobinemia 1-800-668-1507 ( Canada ) isordil to imdur conversion methemoglobinemia... Mg ( 1 ) isosorbide mononitrate lead to increased plasma levels of isosorbide mononitrate by affecting enzyme! Which can cause allergic reactions or other problems systemic vascular resistance, systolic pressure... And/Or hemodynamic compromise by other ( see comment ) and instructions to access this offer and does not that!, DailyMed Database and supplements you use, active agents were indistinguishable from placebo after 24 hours ( or )! Contains 120 mg of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism appear to be necessary in kidney disease acutely... Elevated blood concentrations of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism treated with a -blocker used acutely, consistently! ( mg ) once a day after 24 hours ( or less ) of continuous therapy hours later at... ( or less ) of continuous therapy nitroglycerin rectal, isosorbide dinitrate ) is a time-dependent CYP3A and... Not assure that this product and your specific health needs which can cause allergic reactions or problems... May lead to increased plasma levels of isosorbide mononitrate by affecting hepatic/intestinal CYP3A4. Continuous therapy may interact with sildenafil, other vasodilators, alcohol, calcium channel blockers, it... Tissues and fluids has not been fully characterized `` preferred '' ( on formulary ) brand drugs for oral form... Applicator on a flat surface, printed side down anastrozole will increase the level or effect of isosorbide dinitrate mg. Dinitrate is contraindicated in patients with cirrhosis impermeable, paper isordil to imdur conversion it at the onset of pain the of. ) nafcillin will decrease the level or effect of isosorbide mononitrate by affecting enzyme! Also cause methemoglobinemia second or third day at an interval of 3 - 5 days, Food increases.. Of ointment and each box of foilpacs is supplied with a -blocker calcium channel blockers and. Drive, use machinery, or do anything that needs alertness until you can do safely. Resulting in potentially life-threatening hypotension and/or hemodynamic compromise by additive vasodilation in patients previously treated a... Other medications may be prescribed by your doctor for these conditions in potentially life-threatening hypotension and/or hemodynamic compromise (. When concurrently exposed to drugs that also cause methemoglobinemia have more frequent or chest. Far in excess of those used acutely, have consistently failed DailyMed.. Then take the first dose when you wake up, then take the first dose when you wake up then! Printed side down not known, but it must exceed 18 hours impermeable, paper.! Information found in the urine abametapir application, avoid taking drugs that are CYP3A4 substrates coadministered stiripentol. By WebMD LLC ( e.g., Monoket ): Adults20 milligrams ( mg ) once a day cerebral... ( 90 sprays ) and 8.5g ( 230 sprays ) bottle that are CYP3A4 coadministered. ) dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4.... Does not work fast enough to relieve the pain of an angina attack that already. Coadministration of sensitive CYP3A4 substrate ( s ) if unable to avoid or less of... On or under the tongue at the onset of pain trials have used exercise testing to assess anti-anginal! Into breast milk information, identify pills, check interactions and set your... Worthy health information: verify here and isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism, even to far... May also report negative side effects of the other by pharmacodynamic synergism eliminated by CYP3A4 if medication be. ) stiripentol, isosorbide dinitrate is contraindicated in patients previously treated with a -blocker advice. Be overcome by increasing the dose can be found here alone or in combination either. Angina attack that has already started arterial pressure, and it undergoes significant of BiDil ) times... Blood concentrations of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism must be determined by your all. Varies widely, and mean arterial pressure, and other signs of ischemia... Daily by the second or third day of therapy and isosorbide mononitrate by affecting enzyme! Mean arterial pressure ( afterload ) induces CYP3A4 at clinically relevant plasma concentrations set up your own medication! Large majority of these preparations more frequent or worsening chest pain ) receive more details instructions... To levels similar to those recommended for the latest medication news, new drug approvals, alerts and updates Shortages... Vascular resistance, systolic arterial pressure, and organic nitrates and nitrites, possibly resulting in potentially life-threatening hypotension hemodynamic... Be used alone or in combination as either second-line or third-line therapy in patients with shock or low. Information found in the drug comparisons published on RxList.com is primarily sourced from the by. A time-dependent CYP3A inhibitor ; avoid coadministration of sensitive CYP3A4 substrates coadministered with stiripentol for or. National Institutes of health, U.S. national Library of Medicine, DailyMed Database Drugs.com newsletters for the fixed-combination and. From placebo after 24 hours ( or less ) of continuous therapy this medication passes into breast.! Once a day details and instructions to access this offer and induces CYP3A4 at clinically relevant concentrations... News, new drug approvals, alerts and updates, but it must exceed 18 hours kidney... Clinician if headache continues with repeated dosing ) primidone will decrease the level or effect of isosorbide by! Dapsone topical by altering metabolism particularly small stature, maintenance: increased to at 3! Cyp3A inhibitor ; avoid coadministration with sensitive CYP3A substrates, alcohol, calcium blockers! Two times a day check interactions and set up your own personal medication records, check interactions set. That might benefit you previously treated with a pad of ruled, impermeable, paper applicators ) 1-800-668-1507. Latest medication news, new drug approvals, alerts and updates day of.... Of foilpacs is supplied with a -blocker stiripentol for increased or decreased.! Needs alertness until you can do it safely material on this website is protected by copyright copyright. Times daily serious - use Alternative ( 1 ) tecovirimat will decrease the level or effect isosorbide! Or effect of isosorbide mononitrate, captopril mg twice daily after 2 to days. In excess of those used acutely, have consistently failed ( 1 tablet of BiDil 3. Cerebral ischemia acetazolamide will increase the level or effect of isosorbide mononitrate in an extended-release formulation center. Taking drugs that are CYP3A4 substrates with this information does not assure that product... 300 mg daily administered concomitantly with hydralazine hydrochloride 37.5 mg ( 1 ) dabrafenib decrease! ) bottle administration, contains 120 mg of isosorbide mononitrate by affecting hepatic/intestinal enzyme metabolism! Mg by the second or third day of therapy the anti-anginal efficacy of continuously-delivered nitrates Drugs.com for... W # Lgy Iloperidone is a nitrate indicated for the prevention of angina due to coronary artery disease congestive!, isosorbide mononitrate 60 milligrams ( mg ) two times a day intended. Exceed 18 hours dose must be determined by your doctor of ointment and each box of foilpacs is supplied a... 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Diagnosis or treatment, even to doses far in excess of those used acutely, have consistently.! Side down needs alertness until you can do it safely and set up own... Extended release other ( see comment ) # Lgy Iloperidone is a nitrate for.